Architecture

EOSC-ENTRUST is creating a common European reference architecture to enable secure connectivity and interoperability between Trusted Research Environments (TREs) across Europe. This initiative ensures that researchers can access and analyse sensitive data in a secure, compliant and federated manner.

Project timeline

Click a step to explore the details

May

Requirements and Capabilities Workshop

June

Roadmap for Blueprint

September

Evaluation and Adoption Workshop

January

EOSC-ENTRUST Blueprint and Interoperability Framework

Select a Step on the timeline
to view its details

Step 1

Requirements & Capabilities Workshop

May

The first EOSC-ENTRUST Roadmap Workshop was held in May 2024, bringing together stakeholders, TRE providers and technical experts to:

Define minimal requirements and conceptual models for the Blueprint
Establish a common terminology for interoperability
Identify current challenges and gaps in TRE infrastructure

The insights from this workshop help shape the Blueprint's ongoing development, and future workshops will refine and expand its scope. Download the Requirements and Capabilities Workshop Report.

Step 2

Roadmap for Blueprint

June

The EOSC-ENTRUST Roadmap outlines the development of the Blueprint. The first version (V1) establishes a structured approach for achieving a federated data access and analysis framework, supporting secure cross-border research.

Development phases:

Phase 1 (2024): Identification of Blueprint requirements and mapping existing TRE capabilities
Phase 2 (2025): Development and validation of key components, including security protocols and interoperability solutions
Phase 3 (2026): Finalisation and adoption of the Blueprint across European TRE networks

The Blueprint Roadmap ensures all TREs follow a common architecture, making European research infrastructure more efficient, secure and interconnected.

Step 3

Evaluation and Adoption Workshop

September

In the Evaluation and adoption workshop, the project partners align work across different work packages. The discussions from the workshop help inform adjustments to the Blueprint and training package.

From 17 to 18 September 2026, the project held its second Evaluation and adoption workshop, bringing together project partners to discuss:

The TRE inventory and TRE catalogue
Driver requirements and TRE capability mapping
Adjustments to the Blueprint

The workshop slides are available on Zenodo.

Step 4

EOSC-ENTRUST Blueprint & Interoperability Framework

January

The EOSC-ENTRUST Blueprint defines the foundational architecture, interoperability framework and security model that TREs should follow. By establishing a harmonised approach to data governance, access and analysis, the Blueprint ensures that TREs across different institutions and countries can effectively work together.

The second version of the EOSC-ENTRUST Blueprint and Interoperability Framework presents updated architecture and operational, legal and technical components to support federated access to sensitive research data across Europe. A key focus of this version is the secure and interoperable processing of sensitive data, with particular emphasis on Authentication, Authorisation and Auditing Infrastructure (AAAI), shared identity management and secure data processing mechanisms.

Read the year two version of the EOSC-ENTRUST Blueprint
Read the Training package for EOSC-ENTRUST year two Blueprint and Interoperability Framework
Read the summary news on the year two EOSC-ENTRUST Blueprint

Driving innovation through TREs

EOSC-ENTRUST is validating its Blueprint through real-world use cases across various domains. In genomics research, it supports the secure federated analysis of human genomic data, ensuring privacy while enabling scientific discovery. For clinical trials, it facilitates the cross-border reuse of clinical research data, promoting collaboration and efficiency in medical studies. In the social sciences, it enables the safe sharing of administrative and social data, fostering responsible data use. It also strengthens public-private collaboration by enhancing industry partnerships within secure data environments.

These pilot projects collectively ensure that the EOSC-ENTRUST framework effectively meets the needs of researchers, data providers and policymakers.

What’s next?

EOSC-ENTRUST is evolving through collaborative input and ongoing technical development. Please get in touch if you don’t want to miss out on our latest progress and upcoming events. Contact us.